Endocrine Abstracts

Adrenal incidentalomas are referred as clinically silent adrenal masses discovered incidentally during diagnostic testing or treatment for conditions not related to suspicion of adrenal disease. Certain percent of them are hormonally active and autonomous cortisol secretion is reported with increasing frequency. The aim of the study was to assess value of 1mg-DST in subclinical Cushing’s syndrome (CS) compared to the other forms of adrenal incidentalomas. We have evaluate...

Introduction: Type 2 diabetes mellitus have been associated with excessive production of reactive oxygen species. Glutathione S-transferase (GST) polymorphisms result in decreased or absent enzyme activity and altered oxidative stress. Meta-analyses have indicated that deletion of either GSTM1 or GSTT1 is associated with a significant increased risk of coronary heart disease. The aim of this study was to evaluated if ascorbic acid (AA) plasma levels differ by GST genotype in d...

Introduction: The most important feature of bone metabolism in patients with Cushing’s syndrome is the uncoupling of osteoblast and osteoclast activity resulting in suppressed bone formation.Objective: The aim of the present study was to investigate the altered bone turnover in patients with various forms of Cushing’s syndrome in the active phase of the disease as well as after successful normalization of cortisol overproduction.<p class="a...

Objectives: To describe the results of the bilateral inferior petrosal sinus sampling (BIPSS) performed in our hospital for differential diagnosis between Cushing disease (CD) and ectopic ACTH secretion (EAS), and evaluate if CRH stimulation during this test improves its diagnostic accuracy.Material and Methods: We retrospectively review 29 BIPSS performed in 26 patients (4 men, 22 women), with mean age of 44.7 year-old (range 28–69), diagnosed wit...

Carney’s Triad is a rare syndrome, with fewer than 30 cases reported with all three tumors (Gastrointestinal stromal tumor, extra-adrenal paraganglioma and pulmonary chondroma) present, and less than 100 cases with two of the three tumor types.We report a 45 yr old female who presented with bloating, dizziness, sweating and palpitations. Physical examination was unremarkable. Biochemistry showed a normal hormonal profile, 24 hrs urinary catecholamin...

99mTc-Sestamibi (SeS) is a standard tool for localization of adenomas/hyperplasia (PA) in hyperparathyroidism (HPTH), designed on the difference between thyroid and parathyroid tissue radiotracer washout on early and late scintigraphy phases. However, PA have been reported to washout as fast as normal thyroid tissue (‘rapid washout’, RW), which may lead to diagnostic failure. The aim of the study was to determine a correlation of RW of SeS from parathyroid...

Introduction: A woman’s iodine requirements increase substantially during pregnancy to ensure adequate supply to both mother and fetus. The deficiency of this element may cause several maternal-fetal repercussions. For this reason, iodine supplementation for pregnancy has been recommended and the World Health Organization (WHO) commends an iodine urinary concentration at a median UIC 150–249 μg/l. As in many other countries around the world, there is evidence of...

Introduction: Carcinoid heart disease (CHD) is a rare complication of neuroendocrine tumours (NETs) and carcinoid syndrome (CS). Approximately one in five patients with CS go on to develop CHD, which primarily affects the right side of the heart; leading to thickened, retracted, immobile and regurgitant cardiac valves that ultimately result in right ventricular (RV) dilatation and dysfunction 1 . Patients are referred for valve replacement if they have severe ...

Endometriosis is a hormone-dependent disorder, characterised by growth of endometrial tissue outside the uterus. It has been reported that 30–40% of women with infertility have endometriosis. Transformation of human endometrial stromal fibroblasts (hESC) (termed decidualisation) is accompanied by increased steroid synthesis and is fundamental to the establishment of a receptive endometrial microenvironment, which can support and maintain pregnancy. Evidence suggests that ...

IntroductionVarious direct and indirect mechanisms by which glucocorticoid (GC) excess and elevated adrenocorticotropic hormone (ACTH) levels impairs bone metabolism have been described. In the literature, there are different factors described which affect the early outcome of pituitary surgery in patients with CD including preoperative ACTH levels and the clinical severity of the disease. Combining these data, we conducted a retrospective study to inves...